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Quercetin is formulated in a super saturable - self-nano emulsifying ( SS-SNE ) to increase its stability and bioavailability. This study focuses on the screening design for  SS-SNE  components with a fractional factorial design ( FrFD ) approach and chemometric analysis. The  FrFD  method was chosen because it provides comprehensive benefits. The oil components used are canola and grape seed oil. Croduret 50-SS was selected as a surfactant and PEG 400 as a co-surfactant. The interaction of  SNE  components was evaluated using  FTIR-ATR  instrumentation.  SNE  droplet morphology was observed using a transmission electron microscope ( TEM ). The selected formulas were grape seed oil as oil phase at 19.6%, croduret at 60%, and PEG 400 as co-surfactant with a concentration of 16.6%. The selected formula has a droplet size of 133.27 nm,  PDI  of 0.181, the zeta potential of 17.00 mV, electrophoretic mobility of 1.332 µmcm/Vs, emulsification time of 10.05 seconds, a viscosity of 370.147 mPa.s, and a drug load of 31.70 mg/mL. The components of grape seed oil, croduret, and PEG 400 resulted in a quercetin carrier  SNE  formula that met the criteria.  FrFD  design and chemometric analysis in the screening process can help determine the selected formula very effectively and efficiently.

pharmacia

﻿Understanding the combination of fractional factorial design and chemometrics analysis for screening super-saturable quercetin-self nano emulsifying components

﻿Understanding the combination of fractional factorial design and chemometrics analysis for screening super-saturable quercetin-self nano emulsifying components

Understanding the combination of fractional factorial design and chemometrics analysis for screening super-saturable quercetin-self nano emulsifying components