English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Hyperpigmentation is a disorder of facial skin pigments due to an increase in the process of melanogenesis, which can cause a darkening of skin color. A flavonoid compound with potential as a skin-lightening agent is quercetin, commonly found in    Moringa   oleifera    L. leaves. This study aims to determine quercetin’s affinity and molecular mechanism on tyrosinase enzyme target proteins using an  in-silico  molecular docking method. Docking of quercetin with the tyrosinase enzyme produced a bond energy value of -7.08 kcal/mol. In comparison, the tropolone as a native ligand with the tyrosinase enzyme produced -4.79 kcal/mol. Quercetin has a strong affinity for the tyrosinase enzyme, indicated by the bond energy results from docking. Quercetin extraction from    Moringa   oleifera    L. leaves using three different extraction methods: maceration, soxhlation, and reflux were made. The chromatogram from the TLC-Densitometry method showed the identification result in maceration and soxhlation extract containing quercetin, while reflux extract did not contain quercetin. The highest quercetin was obtained in the maceration method with a level of 21.57% w/w, while the soxhlation received quercetin as much as 18.49% w/w.  In-vitro  tests were carried out using a spectrophotometric method using a comparison of kojic acid. The  in-vitro  test found that IC 50  from kojic acid was 48.90 µg/mL and IC 50  of the extract from moringa leaf maceration of 115.36 µg/mL. Based on this research, quercetin compounds in    Moringa   oleifera    L. leaves from maceration can potentially be skin-lightening agents.

pharmacia

﻿Potency of moringa (   Moringa   oleifera    L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using  in-silico  and  in-vitro  assay

﻿Potency of moringa ( Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay

Potency of moringa ( Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay