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The pathogenesis of essential hypertension through the interaction with elements of the rennin angiotensin aldosterone system is affected by oxidative stress and inflammation. The present study aimed to assess the effects of  ACE -Inhibitor, lisinopril, on blood pressure, lipid profiles (total cholesterol, triglycerides,  LDL  and  HDL ),  MDA , and  TAS ,  hsCRP , and serum leptin levels n hypertensive patients. A case control study included 100 newly diagnosed mild to moderate hypertensive patients and another 100 apparently healthy aged and sex matched subjects as controls. The patients were treated with 10 mg lisinopril orally per day for three months’ duration. Venous blood sample was taken to test levels of  MDA ,  GSH  and  TAS ,  hsCRP , lipid profiles and leptin in the serum before and after lisinopril therapy for both patients and controls. Systolic and diastolic blood pressure were also assessed before and after lisinopril therapy for both patients and controls. In hypertensive patients treated with lisinopril, markers of oxidative stress ( MDA ,  TAS  and  GSH ), high sensitive C-reactive protein and leptin were all found to be decreased significantly after drug treatment (p &lt; 0.01). Lisinopril affectively lowered systolic and diastolic BP values (p &lt; 0.01). A significant decrease in lipid profile (p &lt; 0.01) with a significant increase in  HDL -C and  TAS  levels (p &lt; 0.01) were found in lisinopril treated group in comparison with their values before treatment. Lisinopril may be used as a treatment for high blood pressure, as well as for the insulin resistance, hyperleptinemic, and low-grade inflammatory states that are associated with the disease.

Effect of lisinopril therapy on serum leptin, oxidative stress and C-reactive protein in hypertensive patients