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The objective of this study was to describe two clinical cases of toxicosis by accidental administration of salinomycin in feed in broiler breeders and turkeys. In the first clinical case, a 32000 broiler breeders flock, 30 weeks of age, suffered a severe mortality during the first week, a sharp decrease in egg production and a dramatic reduction in food consumption together with an increase of eating time. The pathological condition manifested itself mainly with leg paralysis and reluctance to move. In necropsy, signs of bile hyper-secretion, absence of feed in the digestive tract, liver degeneration, egg peritonitis, enlarged kidneys and spleen atrophy were found. Serological examinations for IBV, IBD, NDV, Mg, Ms, Ort, TRT, AE and CAA were negative. The broiler breeders flock was finally euthanized due to an irreversible condition, slow recovery and poor production indicators. In the second clinical case, a flock of 27000 turkeys fatteners, aged from 20 to 35 days, showed an increased daily mortality up to 10 and a 88% total death loss in 2 weeks period. The turkeys showed great growth retardation, reluctance to move and eat, ataxia and absence of gross lesions, except atrophy of the spleen and pica. Serological examinations for NDV and AI were negative. After removal and change of feed, the remaining flock recovered normally. These two clinical cases were initially associated with incorrect diet and, after obtaining detailed clinical history, laboratory tests and food analysis, the by error administration of salinomycin in feed was confirmed. The final concentrations of salinomycin in feed analysis reached 64.6-124 mg kg<sup>-1</sup> for the broiler breeders and 298-944 mg kg<sup>-1</sup> for turkeys. While salinomycin toxicosis has been reported worldwide in the literature in a number of animal species, including turkey breeders and fatteners with similar symptoms, in broiler breeders has never been reported on the field

SALINOMYCIN TOXICOSIS IN BROILER BREEDERS AND TURKEYS: REPORT OF THE FIRST CASE