English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

®(alendronate 5 mg plus calcitriol 0.5 µg) daily or Fosamax Plus ® (alendronate 70 mg plus cholecalciferol 2,800 IU) weekly for 1 year. The serum levels of 25(OH)D, parathy roid hormone (PTH), calcium, phosphorus, osteocalcin and N-telopeptide were measured at baseline and after 3, 6, and 12 months of treatment. Results: The data of 72 of the 297 patients were analyzed. In the Maxmarvil ® group (n = 45), the serum PTH significantly decreased by 17% from baseline at 6 months (µd = -6.10; ± 0.85 SE; P < 0.05) and it remained suppressed to 12 months. The serum 25(OH)D tended to increase, but without significance. In the Fosamax Plus ® group (n = 27), the serum 25(OH)D significantly increased by 77% from baseline at 3 months (µd = 9.87; ± 2.32 SE; P < 0.05) and it remained significantly higher than baseline at 6 months ( µd = 3.49; ± 0.86 SE; P < 0.05) and 12 months (µd = 10.47; ± 0.71 SE; P < 0.001). However, the serum PTH showed no significant decrease. In the Maxmarvil ® group, the serum osteocalcin significantly decreased by 26% from baseline at 12 months ( µd = -5.15; ± 0.35 SE; P < 0.05), and in the Fosamax Plus ® group, the serum osteocalcin significantly decreased by 19% from baseline at 6months ( µd = -2.64; ± 0.73 SE; P < 0.05) and it remained suppressed to 12 months (µd = -2.99; ± 0.37 SE; P = 0.32) without significance. Conclusion: Maxmarvil ® and Fosamax Plus ® both improved the bone metabolism in Korean osteoporosis patients. Maxmarvil ® significantly lowered the serum PTH levels, whereas Fosamax Plus ® significantly elevated the serum 25(OH)D levels. (Endocrinol Metab 25:305-309, 2010)

endocrinology and metabolism

The Effects of Combined Treatment of Alendronate Plus Active or Plain Vitamin D on the Vitamin D Metabolism and Bone Turnover Markers in Patients with Osteoporosis