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Review question / Objective: The objective of the proposed study is to examine the relative efficacy of monotherapies for dermatophyte toenail onychomycosis, as per mycological, clinical and/or complete cure rates. Condition being studied: Dermatophyte toenail onychomycosis.  Eligibility criteria: A randomized or observational study with at least one arm investigating the efficacy of antifungal monotherapy for dermatophyte toenail onychomycosis in terms of mycological cure, complete cure and/or clinical cure.

The relative efficacy of monotherapies for dermatophyte toenail onychomycosis: a systematic review with quantitative syntheses of the evidence base