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Review question / Objective: Acupuncture-related therapies are effective Diarrhoea-Predominant Irritable Bowel Syndrome(IBS-D), therefore, our aim was to evaluate and rank the effect of different acupuncture-related therapies for the anxiety-depression status of IBS-D patients. Eligibility criteria: The published randomized controlled trials (RCTs) of acupuncture-related therapies for the treatment of IBS-D, regardless of age and sex. Clear diagnostic criteria were required to confirm the diagnosis of IBS-D, Such as Rome I, Rome II, Rome III, Rome IV, and Chinese expert consensus. Interventions in the treatment group included various types of acupuncture-related therapies, including simple acupuncture (ACU), electroacupuncture (EA), warm acupuncture (WA), moxibustion (MOX), or a combination of acupuncture and drugs; the control group is anti-diarrheal or anti-spasmodic western medicine, or placebo, or comparison between various acupuncture-related therapies. The results of the report are required to include at least one of the following outcome indicators: (1) primary outcome: Hamilton anxiety rating scale( HAMA), hamilton depression rating scale(HAMD), self-rating anxiety scale (SAS), self-rating depression scale(SDS), secondary outcome: Response rate. The language of the publication was limited to Chinese or English.

Acupuncture and Related Therapies for anxiety and depression in Diarrhoea-Predominant Irritable Bowel Syndrome(IBS-D): A Network Meta-Analysis