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Review question / Objective: the PICO question was formulated , in which the following points are identified: Participants (patients with HNSCC), Intervention (altered expression of miR-31 and miR-155 in HNSCC), Control (patients with HNSCC who have low expression of miR-31 and miR-155), Outcome (difference in prognosis of survival among patients with low and high miR-31 and miR-155 expression in HNSCC The PICO question therefore is as follows: Is there a difference in OS (overall Survival) between HNSCC patients with high miR-31 and miR-155 expression versus those with low expression? Condition being studied: Head and Neck Squamous Cell Carcinoma (HNSCC), altered expression of miR-31 and miR-155 tissue.

The Prognostic Role of miR-31 and miR-155 in HNSCC: Protocol