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Review question / Objective: TP73 G4C14-A4T14 variant has been suspected of elevating the risk of cancer for many years. The available evidence was unsatisfactory and could not provide a reliable conclusion. Therefore, we performed this meta-analysis to re-evaluate the previous findings and illustrate the actual role of TP73 G4C14-A4T14 variant on cancer development. Condition being studied: The association of the G4C14-A4T14 variant with cancer risk was studied.  Information sources: PubMed, Google Scholar, EMBASE, Cochrane Library, and Web of Science, CNKI.

Extended Investigation on the connection of TP73 G4C14-A4T14 Polymorphism with different Cancer Types – An Updated Meta-analysis with 56 Case-control Studies