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The theoretical consideration for the use of BBD as a chemotherapeutic agent was previously described1).Briefly stated, it was based on the possible formation of endogenous carcinogens, produced in the course of steroid metabolism.2) This was subsequently amply confirmed by Kennaway and Hieger3),4). The rare occurrence of primary malignancies in the liver and small intestine suggested the presence in bile of a factor, or factors posses sing anti-tumor properties. BBD was found to consist of 95% taurocholic acid and a 5% as yet undetermined component. When combined with 1311-labeled rat globulin, it formed a complex (Fig.1). Scintigraphy proved the BBD complex to concentrate preferentially in tumor tissue (Walker 256 carcinosarcoma)1).In man similar repro ducible results were obtained, when BBD, combined with 13'I-labeled human albumin, or globulin, concentrated preferentially in a variety of human cancers.5),6)As a potential antitumor agent, however, the material proved equivocal'). This prompted the investigation of the 5% component.

A Potential Antitumor Factor (ATF) Isolated from a Bovine Bile Derivative (BBD) (II)