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The identification and assessment of territorial patterns in the formation of spatial structures of the flow of new knowledge is a prominent research topic that needs to be addressed in the context of the formation of a knowledge economy. The traditional center-peripheral model, when the largest core stand out in the world scientific space, interconnected by knowledge pipelines, and knowledge diffuses on to smaller scientific centers, requires revision and refinement. This became possible with the development of spatial scientometric methods to study the processes of creation and diffusion of knowledge. This study focuses on the influence of the agglomeration factor on territorial scientific systems that are forming around cities with a population of more than 1 million people and including research centers of various sizes. In the course of the study, based on the most important scientometric indicators characterizing the magnitude of publication activity, the relevance and competitiveness of scientific output, and integration into national and international networks, scientific profiles of cities of the Russian Federation of various types are formed. The result of the study was to identify the configuration and specifics of scientific centers around millionaire cities in 50 and 100 km zones. It is shown that cities — scientific centers, located 50 km from a millionaire city, have greater scientific connectivity at the national level and are more competitive than other cities on average. At the same time, the level of demand for their scientific products is often lower due to the small size and low recognition of the scientific centers themselves. Cities located in the 50–100 km zone to a lesser extent

Agglomerations of the scientific space of Russia