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High mobility group box-1 (HMGB1), recognized as a representative of damage-associated molecular patterns, is released during cell injury/death, triggering the inflammatory response and ultimately resulting in tissue damage. Dozens of studies have shown that HMGB1 is involved in certain diseases, but the details on how injured hepatocytes release HMGB1 need to be elicited.

High mobility group box-1 release from H2O2-injured hepatocytes due to sirt1 functional inhibition

High mobility group box-1 release from H₂O₂-injured hepatocytes due to sirt1 functional inhibition