English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

SUMMARY Aldose reductase (AR) has been reported to play an important role in sugar-induced cataract. Inthe present study, the AR inhibitory activity of Enicostemma hyssopifolium (EH), Gymnema sylvestre ,Eclipta alba, and Tinospora cordifolia (TC) were studied along with their effect on sugar-inducedcataractogenic changes in sheep lenses in vitro. AR inhibitory activity of the aqueous extracts ofplants and their anticataract potentials were evaluated in vitro in sheep lenses, considering theactivity of normal sheep lenses as 100%. The concentration of the plant extract that showed maximumactivity was selected to further study its effect on galactose-induced polyol accumulation in vitro.The IC 50 values of EH and TC were calculated to be 102 and 85 µg/ml, respectively. EH showed asignificant inhibition (61.3%) in polyol accumulation followed by TC (53.1%). EH and TCpossesses a significant anticataract activity in vitro and its anticataract potential could be relatedwith its AR inhibitory effect. Key words: Aldose reductase; Cataract; Eclipta alba; Enicostemma hyssopifolium; Gymnema sylvestre;Polyol; Tinospora cordifolia

Aldose reductase inhibitory activity and anti catraract potential of some traditionally acclaimed antidiabetic medicinal plants