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These authors contributed equally to this study *Corresponding authors: Meihua Qu, Weifang Medical University, 7166 Baotong West Street, Weifang, 261053 China. E-mail: qumeihua2016@163.com; Weifang Second People’s Hospital, 7 Yuanxiao Street, Weifang, 261041 China; Xiaoyun Yang, Weifang Medical University, 7166 Baotong West Street, Weifang, 261053 China, E-mail: xiaoyuny1118@163.com; Zhiqin Gao, School of Bioscience and Technology, Weifang Medical University, 7166 Baotong West Street, Weifang, 261053 China. E-mail: zhiqingao2013@163.com

Exendin-4 improves glucose metabolism in insulin-resistant cells by upregulating the phosphorylative AMPK