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Cigarette smoke is a pollutant for humans and the environment. Cigarette smoke contains free radical compounds that will lead to oxidative stress. Under oxidative stress condition, the free radicals cause lipid peroxidation of cell membranes and damage the cell membranes organization characterized by increased levels of MDA and the number of macrophages in the lungs. The use of antioxidants from plants such as purple cabbage containing flavonoid compounds is an alternative way to neutralize the increase of malondialdehyde (MDA) and the number of macrophages in the lungs. An experimental study using a post-test control group design was conducted among 36 white male rats (Rattus norvegicus), aged 2-3 months, with a bodyweight of 200 grams. The results showed that the mean level of malondialdehyde (MDA) in the group (P0) was 4.575 ± 2.034, and in the group (P1) was 2.451 ± 1.036 (p <0.001). Whereas the mean number of macrophages in the group (P0) was 4.294±0.619, and the group (P1) was 1.839±0.624, (p < 0.000). These results show a statistically significant of purple cabbage extract administration (Brassica oleraceae var Capitata L.) in male Wistar strain rats (Rattus norvegicus) in reducing the levels of malondialdehyde (MDA) and the number of macrophages in the lungs. Based on the recent findings, it can be concluded that the administration of purple cabbage ethanol extract in male Wistar rats can reduce the levels of malondialdehyde (MDA) and the number of macrophages in the lungs male Wistar strain rats exposed to 3 cigarettes for 14 days.

jurnal ilmiah medicamento

PEMBERIAN EKSTRAK ETANOL KUBIS UNGU (Brassica oleraceae L.) MENURUNKAN KADAR MALONDIALDEHID DAN JUMLAH MAKROFAG JARINGAN PARU TIKUS YANG TERPAPAR ASAP ROKOK