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Background: Overweight and obesity among children and adolescents is an epidemic on the rise, as management strategy behavioral therapy is not sufficient for sustained weight reduction and therefore pharmacological treatment is the need of the hour. Aims and objectives: This study aimed to determine the effect of diet, an exercise in combination with Orlistat on weight and BMI of the obese patients. Materials and methods: In this prospective observational study, we studied the effects of orlistat, exercise and diet on BMI and body weight in a cohort of 100 obese subjects aged between 11-40 came at Harmony Super speciality clinic 62 old MLA Qts, Jawahar Chowk Bhopal. Results: Majority of the patients were young and working-age group (21-40 years). We found that orlistat has a significant role in weight reduction, posttreatment average reduced by 20 kg, post-treatment BMI reduced by 8 kg/m2 and HbA1c reduced by 2% after treatment. Patients who were on low-calorie diet i.e. consumed only 1000-1100 kcal recorded a weight loss of 28.92 ± 6.41% and BMI reduction of 23.75 percentage. Subjects who did exercise for >75 min per day recorded a weight loss of 28.71 ± 7.01% and BMI loss of 21.57 ± 7.24 percentage. Conclusion: Orlistat in combination with low calorie diet and exercise has shown statistically significant weight and BMI reduction among the obese subjects.

Study of Effect of Low-Calorie Diet, Exercise and Orlistat on Weight and BMI of the Obese Patients: A Prospective Study