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Many virus need their sulphydryl groups to be reduced in order to be allowed to enter cells. SARS-CoV-2, which belongs to Coronaviridae family, and is responsible for coronavirus disease 2019 or COVID-19, has cysteine-rich proteins in its capsid as the main CoV protease (M PRO ), which must be intact and active maintaining the viral activity. Considering that M PRO is an important molecular target for development of antiviral drugs, this work motivation was the structural study of the possible ways of interaction between drugs and viral cysteines by molecular docking technique for design of new potential inhibitors of M PRO and its virulence.

CORONAVÍRUS E SUA PROTEASE PRINCIPAL: UMA VISÃO PARA O PLANEJAMENTO DE FÁRMACOS POR DOCAGEM MOLECULAR