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Systemic delivery of drugs through nasal route requires extended residence time in nasal cavity. The aim of the present work is to fabricate an In-Situ nasal gel using thermoreversible polymer, PF-127 and mucoadhesive polymers HPMC E15 and PEG 6000 to improve the residence time and easy application of accurate dosage. Optimization of formulations was carried out in terms of their content uniformity, clarity, pH, gelation temperature, viscosity, mucoadhesive strength and spreadability. Drug-excipient compatibility was ascertained by FT-IR Spectroscopy. Optimization of PF-127 concentration (20 and 25%) was done to get gelation temperature of formulations in the nasal physiological temperature range (25-34°C). The regression value of ex vivo permeation kinetic study show highest linearity for F1 and F2 to the Higuchi Model whereas F3, F4, F5, F6 to the first order model & the ‘n’ value of each formulation shown that F1, F2 follow NonFickian release and F3, F4, F5, F6 follow Super Case II release mechanism. The value of exponent ‘n’ of Korsmeyer-Peppas model suggests the permeation from F1 & F2 is diffusion & erosion controlled, and F3, F4, F5 & F6 is due to the erosion of the polymeric chain. It can be concluded that as viscosity of the formulation is increased the release mechanism will transform from Non – Fickian to Super Case II release mechanism. Hence a clear In-Situ gel may be formulated using PF 127 which is a stable under accelerated conditions and releases the drug under controlled manner for sustained systemic delivery through nasal route.

Formulation Optimization, Permeation Kinetic and Release Mechanism Study of In-Situ Nasal Gel Containing Ondansetron