English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The objective of present investigation is to prepare and optimize an oral floating alginate gel beads of Diclofenac sodium using sodium alginate and oils was utilized as a dispersed phase to generate a uniform emulsion to create multiple tiny chambers in the alginate matrix for better buoyancy. Diclofenac sodium loaded beads were prepared by emulsion gelatin method. In this method pre gelation liquid of sodium alginate solution (2-4% w/v) was prepared. Oil (Light liquid paraffin, coconut oil, and olive oil) in the concentration (10%, 20% and 30%, was then added to the polymer solution. From the results formulation F3 was chosen as the most optimized formulation as it possessed all the required physicochemical characters and sustained drug release. The in vitro release data fitted with higher values in matrix model and the release was found to be NonFickian diffusion (anomalous transport) as the n value is in between 0.5 to 1. Entrapment efficiency and drug release of optimized batch FL3 were found to be 78.22% and 92.63% respectively. Drug absorption from the gastrointestinal tract is highly variable process and prolonging gastric retention of the dosage form is a challenging task. Under such circumstances, floating drug delivery system proves to be promising approach for gastric retention. The optimization of floating, drug entrapment efficiency and drug release behavior of Diclofenac beads was done by applying design expert

Formulation and Optimization of Oil Entrapped Floating Alginate Beads of Diclofenac Sodium