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Case Report Neurological manifestations are various and prevalent in SARS-CoV-2. Recent clinical evidences are suggests various silent neurological involvements are observed and it is an important aspect of this disease. The underlying mechanisms may includes both endothelial cell dysfunction and von-Willebrand factor inflammatory responses. Further studies must be conducted to explore the role of neurological manifestations in SARS-CoV-2 progression and must verify their underlying mechanisms. Many patients are developed a mild-to-moderate form of Neurological symptoms in the SARS-CoV-2 disease. SARS-CoV-2 mortality risk is higher in elderly patients and in patients with cerebrovascular diseases and coronary vascular diseases. Molecular mechanisms which underlie these risks are not yet understood for SARS-CoV-2. Here we discuss a possible association of SARS-CoV-2 complications with von Willebrand factor (VWF) level and endothelial damage. Von Willebrand factor is an important prognostic indicators of endothelial dysfunction and its level varies depends on sex and age. Significantly, a drug chloroquine, that showed potential efficacy for SARS-CoV-2 treatment, can influence VWF secretion and consequently its level and activities. We propose that varies in the VWF levels and its activities might be predictors of the SARS-CoV-2 morbidity and mortality, moreover the VWF might be involved in the pathogenesis of the disease. We also suggest that a comprehensive study of VWF level in SARS-CoV-2 positive groups of people with mild and severe course of the disease should be undertaken.

A Case Report on: Non-Symptomatic SARS-CoV-2 Results in Adverse Neurological Symptoms - Von Willebrand Factor (VWF) May Have A Casual or Causal Link