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Original Research Article Introduction: Thyroid disorders in pregnancy are receiving attention from many scientific corners. Over the past several years it has been proved that maternal thyroid disorders influence the outcome of mother and fetus during and also after pregnancy. Material & Methods: This observational and longitudinal study encompassed 300 pregnant mothers who were recruited on consecutive basis in their first trimester from the department of Obstetrics and Gynecology. BSMMU and antenatal clinic of a maternity hospital after fulfillment of inclusion criteria. Assay for antithyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies as well as free thyroxin (FT4) and thyroid stimulating hormone (TSH) were done by automated chemiluminescent method. Study subjects were categorized into normal and disorder groups on the basis of American thyroid association (ATA) defined criteria and all pregnant women were followed throughout the pregnancy till delivery, to note any adverse feto-maternal outcome. Results: Mean maternal age (±SD) was 25.68±4.50 years. Median gestational age on recruitment in the first trimester was 11.0 weeks. Most of the mothers were housewife (74.0%) followed by service holder (19.3%) and students (6.7%). About one third mother (29%) had history of previous abortion; 37% were primigravida and 46% were nulliparous indicating abortion or miscarriage in some mothers. Out of 300 pregnant mothers more than 200 were negative for both antibodies, 28 were positive for both antibodies, while 50 were positive for only anti-TPO and 12 were positive for only anti-TG (p<0.001, by McNemar’s test). These frequencies for euthyroid (n=19): 6,8, 4 and 1 (p=0.375), for hypothyroid (n=7): 2,0,4 and 1 (p=0.375), for SCH (n=102): 69, 10, 18 and 5 (p=0.011) and for subclinical hyper (n=9): 5,2,2 and 0(p=0.500) respectively. When antibody status was considered combined 90 subjects were positive and 210 were negative. Frequencies of positive and negative antithyroid antibodies status among various subclasses were found to be disturbed differently. Hypertension-preeclampsia was found in 24, spontaneous abortion 24, placental abruption 2, Caesarean section in the dysfunction group (euthyroid vs. dysfunction: hypertensionpreeclampsia 45.8% vs. 54.2%, p= 0.505, placental abruption 0% vs. 100%, p=0.137, Caesarean section 48.6% vs. 51.4%, p= 0.094). Conclusion: Maternal and fetal complications may be reduced if treatment is given when dysfunction is detected earlier in pregnancy.

scholars journal of applied medical sciences

A Comparison between Anti-Thyroid Antibody Positive Euthyroid and Anti-Thyroid Antibody Negative Euthyroid in Pregnancy: A Study in a Tertiary Care Hospital, Dhaka, Bangladesh