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Original Research Article Introduction: Post-operative blood loss remains a major problem after cardiopulmonary bypass. The increased bleeding tendency after cardiac surgery using cardiopulmonary bypass is a complex result of multiple hemostatic defect including coagulation factor deficiency, inadequate neutralization of heparin, increased fibrinolytic activity & platelet deficiency in quantity & quality. In this study effect of Fresh Frozen plasma on post-operative blood loss was evaluated. Objective: To evaluate the relation between post-operative blood loss and transfusion of fresh frozen plasma of the patient undergoing cardiac surgery with cardiopulmonary bypass. Materials and Methods: This comparative cross sectional study was carried out at the department of cardiac surgery in BSMMU hospital. The study population was 60, with each group having 30 patients. Grouping of patients were done with respect to transfusion of fresh frozen plasma (group a patients who were received FFP and whole blood & group B: patients who were received whole blood only). Demographic, pre-operative and post-operative data were analyzed statistically to establish the hypothesis. There was significant difference in age, cross clamp time, total bypass time between two groups. Results: Total sixty (60) patients who underwent cardiac surgery with cardiopulmonary bypass were included in this study as per the inclusion and exclusion criteria. Patients were grouped into group A and B on the basis of per-operative & post-operative transfusion. Patient in group A received FFP & blood whereas patients in group B received whole blood only. Surgical procedure and ICU care were adopted on standard hospital protocol. Among the study population mean age in group A was 27.43±7.53 years and in group B was 32.37±7.54 years. The difference in age between two groups was statistically significant (p<0.05). There was no statistical significance of gender between the two study groups (p>0.05). The mean BMI in group A was 24.13±2.49 kg/m2 and that in group B was 24.62±3.71 kg/m2. The findings were not statistically significant (p>0.05). Blood loss was significantly greater in group B compared with group A within 48 hours of operation and also patients in group B had longer ventilation time, ICU stay and hospital stay. Regarding Pearson’s co relation test, cross clamp time was positively and amount of FFP transfusion was negatively co relate with post-operative blood loss. Variables that have significant relationship with post-operative blood loss were not showed significance in multivariate binary regression analysis, so only transfusion of fresh frozen plasma mostly related to post-operative blood loss following cardiac surgery with cardiopulmonary bypass. Conclusion: From this study it reveals that per-operative and post-operative transfusion of Fresh Frozen plasma can effectively reduce post-operative blood loss especially in on-pump cardiac surgery as well it reduces post-operative morbidity, hospital stay.

scholars journal of applied medical sciences

“Relation between Per-Operative and Post-Operative Tranfusion of Fresh Frozen Plasma and Post-Operative Blood Loss in the Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass”