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Original Research Article Introduction: Microorganisms cause septicaemia, a systemic disease due to their multiplication and toxins in the blood. Microorganisms present in the circulating blood whether continuously, intermittently or transiently are a threat to every organ of the body. These blood stream infections constitutes a significant public health problems and a major cause of morbidity and mortality in the hospitalized patients. Hence it requires rapid antimicrobial treatment. Infection by multidrug resistant (MDR) organisms are more likely to increase the risk of death in these patients. Aims & Objectives: To determine the microbiological profile in suspected adult septecamic patients admitted in ICU and different wards at VIMSAR, Burla and their antimicrobial sensitivity pattern. Materials and Methods: Study was carried out at VIMSAR, Burla with a total number of 246 admitted adult patients having suspected septicaemia. The blood culture samples were processed in Microbiology Laboratory using standard procedure by conventional method. The pathogenic microorganism were identified and antimicrobial sensitivity was done as per CLSI guidelines. (Clinical laboratory and standard institute). Results: Out of 246 suspected adult septicaemic patients, 32 (13.01%) developed septicaemia with the positive blood culture. Out of the 32 positive culture, 28 (87.5%) showed bacterial growth, in which 17 (53.13%) were gram positive cocci, 11 (34.37%) were gram negative bacilli and 4 (12.50%) isolates were gram positive budding yeast cells. Most common isolates were Staphylococcus aureus (31.25%), Enterococcus spp. (21.87%), Klebsiella spp. (15.62%) followed by Pseudomonas aeruginosa (9.37%), Candida spp. isolated were 12.50%. Antibiotic sensitivity pattern of gram positive bacteria (Staphylococcus aureus and Enterococcus spp.) showed high sensitivity to Vancomycin and Linezolid, 100% each. Gram negative bacteria, Enterobacteriaceae family showed a higher rate of resistance as compared to Gram positive bacteria. Imipenem resistance was seen in 12.5% Gram negative Bacteria which is an alarming sign. Conclusion: The present study provides much needed information on the prevalence of bacterial pathogens in blood stream infections (BSI) and also demonstrates the presence of fungemia due to Candida spp. The timely detection of bacteremia and fungemia followed by expeditious identification of pathogen and determination of susceptibility to antimicrobial agents can have great diagnostic and prognostic importance and thus preventing morbidity and mortality. Keywards: BSI, MDR, CLSI, Septicaemia, Blood Culture. Copyright @ 2020: This is an open-access article distributed under the terms of the Creative Commons Attribution license which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use (NonCommercial, or CC-BY-NC) provided the original author and source are credited.

Microbiological Profile and Antimicrobial Sensitivity Pattern of Suspected Adult Septicaemic Patients at VIMSAR, Burla