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Formation of amyloid fibrils of various amyloidogenic proteins isdramatically enhanced by ultrasound irradiation. For applying this phenomenonto the study of protein aggregation science and diagnosis of neurodegenerativediseases, a multichannel ultrasound irradiation system with individuallyadjustable ultrasound-irradiation conditions is necessary. Here, we develop asonochemical reaction system, where an ultrasonic transducer is placed in eachwell of a 96-well microplate to perform ultrasonic irradiation of samplesolutions under various conditions with high reproducibility, and applied itfor studying amyloid-fibril formation of amyloid $\beta$, $\alpha$-synuclein,$\beta$2-microglobulin, and lysozyme. The results clearly show that ourinstrument is superior to conventional shaking method in terms of degree ofacceleration and reproducibility of fibril formation reaction. The accelerationdegree is controllable by controlling the driving voltage applied to eachtransducer. We have thus succeeded in developing a useful tool for the study ofamyloid fibril formation in various proteins.

Acceleration of amyloid fibril formation by multichannel sonochemical reactor