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: This study was aimed to prove that administration of black cincau (Mesona palustris BL) leaf extract increased superoxide dismutase (SOD) levels of overtraining-induced male Wistar rats (Rattus norvegicus). This was a true experimental study using the randomized pretest-posttest control group design. Subjects were 16 male rats (Rattus norvegicus), 6-month old, Wistar strain, weighing 180-200 g, SOD level 0.05). After 14-day treatment (posttest), the mean SOD level in the P0 group was 29.36±2.83 U/mL while in the P1 group was 41.31±2.35 U/mL (P 0.05), but in the P1 group there was a significant increase of SOD levels from 31.31±2.52U/mL to 41.31±2.35U/mL (P 0,05). Setelah perlakuan selama 14 hari (posttest), rerata kadar SOD pada kelompok P0 ialah 29,36±2,83 U/mL, dan pada kelompok P1 ialah 41,31±2,35 U/mL (P 0,05), namun pada kelompok P1 terjadi peningkatan bermakna kadar SOD dari 31,31±2,52 U/mL menjadi 41,31±2,35U/mL (P <0,01). Simpulan: Ekstrak daun cincau dosis 54 mg/200 gr BB tikus dapat meningkatkan kadar SOD tikus Wistar (Rattus norvegicus) jantan yang diinduksi pelatihan fisik berlebih. Kata kunci : daun cincau, SOD, aktivitas fisik berlebih

jurnal biomedik : jbm

Pemberian Ekstrak Daun Cincau (Mesona palustris BL) Meningkatkan Kadar Superoksida Dismutase (SOD) Tikus Wistar (Rattus norvegicus) Jantan yang Diinduksi Latihan Fisik Berlebih