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Plant isolated phytochemicals have been used since ancient times as both primary and supplemental treatment for various ailments as well as to support normal physiological functions. Phytochemical based pharmacological interventions recently received a great attention for the treatment and prevention of inflammatory and chronic diseases including cancer, diabetes, cardiovascular, hepatic and neurological diseases. Anti-inflammatory effects of phytochemicals are mediated by the modulatory actions on multifaceted cell signalling pathways including inflammatory transcription factors, cytokines, redox status, protein kinases, and enzymes that generally promote inflammation. Imbalance redox status has been reported to be associated with the pathogenesis of chronic disease. Phytochemicals have the ability to correct oxidative stress by modulating redox status and cure various chronic diseases. Based on in-vitro, in-vivo and human data, this study summarizes the recent knowledge regarding the potential effect of various phytochemicals via cellular transduction pathways and provides an in depth assessment of therapeutic value in the treatment and prevention of various chronic inflammatory diseases.

Pharmacological Intervention of Phytochemical Therapy for Inflammatory and Chronic Diseases