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Thiamine, known as vitamin B1, has pivotal role in energy metabolism (Lonsdale, 2006). Thiamine is the main compound of thiamine pyrophosphate which is a cofactor of enzymes involved in glucose metabolism. Allithiamine is a lipid soluble form of vitamin B1, which was found firstly in Allium genus (Fujiwara et al., 1954). In our preliminary experiment, the effect of allithiamine was investigated in streptozotocin-induced diabetic mice. The results confirm the improvement of neuropathic pain sensation (Biro et al., 2018). Diabetes mellitus (DM) is a metabolic endocrine disorder with serious microand macrovascular complications. The latest prognosis of the World Health Organization (WHO) predicted an increasing prevalence of DM. DM is accompanied by hyperglycaemia, which may cause tissue damage by several mechanisms (Berrone at al., 2006). One of the major metabolic route is the nonenzymatic glycation of intraand extracellular proteins, lipids, nucleic acids resulting in advanced glycation end-products (AGEs) (Nin et al., 2011). Increased level of AGEs leads to harmful intermediates causing enhanced oxidative stress and consequential inflammation (Zhang et al., 2003). Several studies suggest that the increased formation of AGEs is major cause of endothelial dysfunction in DM. It has been suggested that unphosphorlylated thiamine and its synthetic derivatives can alleviate endothelial dysfunction by inhibiting AGEs pathway (Balakumar et al., 2010; Brownlee, 2005). The object of this study was to examine effect of allithiamine compared to thiamine in primary cultured human umbilical cord vein endothelial cells (HUVECs) as hyperglycaemic model investigating level of AGEs. MATERIALS AND METHODS

Effect of allithiamine on the level of hyperglycaemia-induced advanced glycation end products