English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Phages 933W, BAA2326, 434, and λ are evolutionarily-related temperate lambdoid phages that infect  Escherichia coli . Although these are highly-similar phages, BAA2326 and 933W naturally encode Shiga toxin 2 (Stx + ), but phage 434 and λ do not (Stx − ). Previous reports suggest that the 933W Stx +  prophage forms less stable lysogens in  E. coli  than does the Stx −  prophages λ, P22, and 434. The higher spontaneous induction frequency of the Stx +  prophage may be correlated with both virulence and dispersion of the Stx2-encoding phage. Here, we examined the hypothesis that lysogen instability is a common feature of Stx +  prophages. We found in both the absence and presence of prophage inducers (DNA damaging agents, salts), the Stx +  prophages induce at higher frequencies than do Stx −  prophages. The observed instability of Stx +  prophages does not appear to be the result of any differences in phage development properties between Stx +  and Stx −  phages. Our results indicate that differential stability of Stx +  and Stx −  prophages results from both RecA-dependent and RecA-independent effects on the intracellular concentration of the respective  c I repressors.

Mechanisms that Determine the Differential Stability of Stx+ and Stx− Lysogens