English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Fusarium fungi are the cause of an array of devastating diseases affecting yield losses and accumulating mycotoxins. Fungicides can be exploited against Fusarium and deoxynivalenol (DON) production. However, Fusarium resistance to common chemicals has become a therapeutic challenge worldwide, which indicates that new control agents carrying different mechanisms of action are desperately needed. Here, we found that a nonantibiotic drug, ethylenediaminetetraacetic acid disodium salt (EDTANa 2 ), exhibited various antifungal activities against Fusarium species and DON biosynthesis. The infection of wheat seeding caused by F. graminearum was suppressed over 90% at 4 mM EDTANa 2 . A similar control effect was observed in field tests. Mycotoxin production assays showed DON production was significantly inhibited, 47% lower than the control, by 0.4 mM EDTANa 2 . In vitro experiments revealed a timely inhibition of H 2 O 2 production as quickly as 4 h after amending cultures with EDTANa 2 and the expression of several TRI genes significantly decreased. Chitin synthases of Fusarium were Mn 2+ -containing enzymes that were strongly inhibited by Mn 2+ deficiency. EDTANa 2 inhibited chitin synthesis and destroyed the cell wall and cytomembrane integrity of Fusarium , mainly via the chelation of Mn 2+ by EDTANa 2 , and thus led to Mn deficiency in Fusarium cells. Taken together, these findings uncover the potential of EDTANa 2 as a fungicide candidate to manage Fusarium head blight (FHB) and DON in agricultural production.

toxins

Ethylenediaminetetraacetic Acid Disodium Salt Acts as an Antifungal Candidate Molecule against Fusarium graminearum by Inhibiting DON Biosynthesis and Chitin Synthase Activity