English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

It is well known that activated microglia produce nitric oxide (NO), which has an important role in the pathophysiology of several neurodegenerative diseases such as Alzheimer’s disease. In the course of searching for novel therapeutic agents from medicinal plants against neuroinflammatory diseases, the methanolic extract of  Tetrapanax papyriferus  was found to have significant NO inhibitory activity in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. Nine oleanane-type triterpenes, including two new compounds, epipapyriogenin C-3- O -β- d -glucopyranoside ( 6 ) and 11- O -butylpapyrioside LIIc ( 9 ), were isolated from the leaves and stems of  Tetrapanax papyriferus . The structures of these compounds were elucidated with 1D- and 2D-NMR and MS data. Among these Δ 11,13  oleanane-type triterpenes, compound  3  showed significant NO inhibitory activity in BV-2 cells, reducing the LPS-induced expression of COX-2 and pro-inflammatory cytokines such as TNF-α and IL-6. Compounds  7  and  9  also showed NO inhibitory activities among the Δ 12  oleanane-type triterpene saponins. These results show that oleanane-type triterpenes isolated from  T. papyriferus  could be a potential natural resource of NO inhibitors used in the treatment of neurodegenerative disorders.

Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus