English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Chemical investigation of the methanol extract of the Vietnamese marine sponge Ircinia echinata led to the isolation of six new 9α-hydroxy-5α,6α-epoxysterols: 5α,6α-epoxycholesta-7,22( E )-dien-3β,9α-diol ( 1 ), 5α,6α-epoxycholesta-7,24(28)-dien-3β,9α-diol ( 2 ), (24 R )-5α,6α-epoxy-24-ethyl-cholesta-7-en-3β,9α-diol ( 3 ), 5α,6α-epoxycholesta-7-en-3β,9α-diol ( 4 ), (24 S )-5α,6α-epoxyergosta-7,22-dien-3β,9α-diol ( 5 ), and (24 R )-5α,6α-epoxy-24-methyl-cholesta-7-en-3β,9α-diol ( 6 ) along with the known 5α-6α-epoxysterols: 5α,6α-epoxystigmasta-7-en-3β-ol ( 7 ), 5α,6α-epoxystigmasta-7,22-dien-3β-ol ( 8 ), and 5α,6α-epoxyergosta-7-en-3β-ol ( 9 ). Their structures and their configurations were established on the basis of high resolution mass spectra and extensive 1D and 2D NMR spectroscopic data and by comparison with the literature. Their cytotoxic activity, evaluated against three human cancer cell lines, MCF-7, Hep-G2 and LU-1, revealed that only compounds 3 and 4 exhibited significant antiproliferative activity and compound 3 showed a selective inhibition towards the MCF-7 human breast cancer cells.

New 9α-Hydroxy-5α,6α-epoxysterols from the Vietnamese Marine Sponge Ircinia echinata