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Creatine and sodium bicarbonate are both ergogenic aids for athletic performance. However, research on the combined creatine and sodium bicarbonate (CSB) supplementation in soccer is limited. This study investigated the changes in soccer-specific performance in elite soccer players after supplementing with CSB. Twenty well-trained elite soccer players participated in the study (age: 20.70 ± 1.08 years; height: 173.95 ± 2.81 cm; body weight: 70.09 ± 3.96 kg; soccer experience: 8 years; average training hours per week: 20 h). The participants were randomly allocated into CSB groups (CSB, n = 10) and placebo groups (PLA, n = 10). The CSB group took creatine (20 g/day) and sodium bicarbonate (0.3 g/kg/day); these two supplements were taken four times a day (morning, afternoon, evening, and before sleep) for seven days. Soccer-specific performance was assessed via 10- and 30-m sprint, coordination, arrowhead agility, and Yo-Yo intermittent recovery level 1 tests. Compared to the PLA group, the CSB group performed better in the 30-m sprint (CSB: -3.6% vs. PLA: -0.6%, p = 0.007, effect size (ES): 2.3) and both right and left arrowhead agility (right: CSB: -7.3% vs. PLA: -0.7%, p &lt; 0.001, ES: 2.8; left: CSB: -5.5% vs. PLA: -1.2%, p = 0.001, ES: 2.1) tests. However, there were no differences in 10 m sprints, coordination, and Yo-Yo intermittent recovery level 1 tests between the two groups ( p &gt; 0.05). In conclusion, CSB supplementation improved sprint and agility in elite soccer players. However, it is still unclear whether such effect is synergistic effect of two supplements or the result of either one of them. Therefore, caution should be taken when interpreting the results, and the limitations should be examined further in future studies.

international journal of environmental research and public health

Effects of Combined Creatine and Sodium Bicarbonate Supplementation on Soccer-Specific Performance in Elite Soccer Players: A Randomized Controlled Trial