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3-​Chloromethyl oxacephem as a 5-oxa-1-azabicyclo[4.2.0]oct-2-en-8-one heterocycle displayed the potent antibacterial activity against both Gram-positive and Gram-negative bacteria. Importantly, it can be used as a starting material to synthesize Latamoxef and Flomoxef. However, the industrial route of 3-​chloromethyl oxacephem is trival and low yielding. Therefore, discovery a Simple and productive synthetic method is very necessary. The inexpensive 6-Aminopenicillanic acid was used to obtain the 3-​chloromethyl oxacephem in our group.

proceedings of the 21st international electronic conference on synthetic organic chemistry

&lt;strong&gt;Industrial &lt;/strong&gt;&lt;span&gt;&lt;strong&gt;Method for preparing 3-​chloromethyl oxacephem antibiotic nucleus&lt;/strong&gt;&lt;/span&gt;

<strong>Industrial </strong><span><strong>Method for preparing 3-​chloromethyl oxacephem antibiotic nucleus</strong></span>

<strong>Industrial </strong><span><strong>Method for preparing 3-chloromethyl oxacephem antibiotic nucleus</strong></span>