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The peak oxygen consumption (VO 2  peak) serves as a prognostic factor in cardio-respiratory diseases and plays an important role in cancer patients. The long-term prognostic relevance of VO 2  peak in lung cancer patients has not been investigated extensively. The aim of this study was to evaluate the impact of the preoperative VO 2  peak on the postoperative long-term survival in patients with operated lung cancer. Retrospective analysis of 342 patients with curatively resected non-small-cell lung cancer using a multivariate Cox proportional hazard model. Results: Preoperative VO 2  peak ranged from 10.2 to 51.8 mL/kg/min (mean: 18.3 ± 4.6), VO 2  peak % of predicted ranged from 32 to 172% (mean: 65.2 ± 18.0%). Overall 10-year survival was 23%. A Log-rank test comparing predicted VO 2  peak ≥ 60% with predicted VO 2  peak < 60% showed overall survival of 30% and 17%, respectively ( p  < 0.001) and non-tumour-related survival of 71% and 51% ( p  = 0.001) at 10 years. In multivariable Cox analysis, overall 10-year survival correlated with a high predicted VO 2  peak% ( p  = 0.001) and low N-stage corresponding to N0 and N1 ( p  < 0.001). Non-tumour-related death correlated with low VO 2  peak% of predicted ( p  = 0.001), and age ( p  < 0.001). Low preoperative VO 2  peak was associated with both decreased postoperative overall survival and decreased non-tumour-related survival during the 10-year follow-up.

Preoperative Peak Oxygen Consumption: A Predictor of Survival in Resected Lung Cancer