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In advanced Parkinson&amp;rsquo;s disease, the pedunculopontine nucleus region is thought to be abnormally inhibited by gamma-aminobutyric acid (GABA) ergic inputs from the over-active globus pallidus internus. Recent attempts to boost pedunculopontine nucleus function through deep brain stimulation are promising, but suffer from the incomplete understanding of the physiology of the pedunculopontine nucleus region.

Pallidal Stimulation Modulates Pedunculopontine Nuclei in Parkinson’s Disease