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Invasive  Candida  infections have become a global public health problem due to the increase of  Candida  species resistant against antifungal therapeutics. The glucocorticoid PYED-1 (pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1) has antimicrobial activity against various bacterial taxa. Consequently, it might be considered for the treatment of  Candida  infections. The antifungal activity of PYED-1 was evaluated against several fungal strains that were representative of the five species that causes the majority of  Candida  infections—namely,  Candida albicans ,  Candida glabrata ,  Candida tropicalis ,  Candida parapsilosis  and  Candida krusei . PYED-1 exhibited a weak antifungal activity and a fungistatic effect on all five  Candida  species. On the other hand, PYED-1 exhibited a good anti-biofilm activity, and was able to eradicate the preformed biofilms of all  Candida  species analyzed. Moreover, PYED-1 inhibited germ tube and hyphae formation of  C. albicans  and reduced adhesion of  C. albicans  to abiotic surfaces by up to 30%.

The Glucocorticoid PYED-1 Disrupts Mature Biofilms of Candida spp. and Inhibits Hyphal Development in Candida albicans