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فادهلأا  مةميت تةلا ةساردلا فدهت: رةاضلا ررةثلأا  رةولا ة ةيلا الاةهل رةبرهتللال تةلع  ار ةلاةو مة رع اة مةك ةمكةت  رةفلا امك لةت ا 6  تضة برعل ي . ا ضلا ثللا برهتلا رطو داوملا قئا  لمعلا  ( مكةتب ضفلا رولا ةيلا الاه ةماحت ت : 2 % اة ) . رولا ةيلا ق حس تلع ساردلا ةج  تلضش مئا شعلا يةيةسلا بررجتلا  ( 45 ضية )  برص  ا ةضلا ةثللا برةهتلأب تةح اةت  ( امب هررضعأ 18 50 راية ةشع سضخ ات ع ضج مك عم رج ثلاث تلا ا ضسق, وس) ,  ينم رةنم ملاةع اضةاتت ت رك جلرعضلا , يئا دلا ملاعلا ث رمعلا ي نروسلأا عمضلت فمظوتل تل لاا ع ضجضلر ملاعلا ت دوتسأ  دوتةسا ةم رثلا ع ضجضلا, طي ينم رنمضلا ت  دوتسا ثلرثلا ع ضجضلا ر ا يعض ضلا ايدمسنمه ر لنلا الاه ت رولا ةيلا الاه رمعض سي , مضعت  ا ةملا ية امتة ملاعلا   تةيبي  دضل  عمبرسا ثلاث دضل مقلاا تلع قيرق ةشع مةقلأا تةلع ةة مةنل تم لاةسلا ةةسا ب ثحتسضلا ةمغ برعللا عضج تي ث, 2  دةعب عرةس برةعللا اااةة أ تلع ءاذغلا مفحت ةمثأت رعبتسلأ ارعةلا ل روت .  امك ةلةت ا اة مةك كرةمق ةت 6  ار ةلاةو مة رع  برةعللا ية رةفلا روضلا كرمق ارهج ةسا ب ( ي لارب طبتةضلا ع ELISA ) نر دةية ررةبتخأ عم رةجضلا امةب رة رمبلا مةملحتل منس ةك رربتخأ اادوتسأ ت. . دحا لا ع ضجضلا للاخ و الأل  جئاتنلا أ: ةهظ جئرتولا  ةمكةت لدةع ية مئرةصحأ ةللا ةج ادةع تةلا ةساردلا ذةهل مئرصحلأا امك لةت لأا 6  ي ملاعلا دعب برعللا ي ار ةلاةو مة رع ا تةسضل رةي وع رةضرفو أ جئرتولا ةهظأ رضومب ثلاثلا عم رجضلا  ية رةفلا دعب رولا ةيلا ع ضجضل برعللا 21  مسرميلا تل لأا ع ضجضلا ع رريضلا دوع ملاعلا ةت ا ا ي . اااتنتتسلأا :  نأ  مةج اادوتةسأ لاتخأ ثللا برهتللأ را ةمثأت هل رولا ةيلا ف مكةت ا مك  امك لةت لأا 6  ار لاةو م رع –  ن ةني نأ اةنضي برةعللا ية رةفلا صموشت ي دعرسي ةشؤ  ثللا ضاة أ .  ABSTRACT Aims: The study aimed to evaluate the anti-inflammatory effects of nanocinnamon gel on salivary concentrations of cytokines: interleukine-6( IL-6) and tumor necrosis factor-alpha ( TNF-α) in chronic gingivitis.Material and Methods: prepared nanocinnamon gel 2% concentration from nanocinnamon powder. The study was carried out on the randomized clinical trial of chronic gingivitis comprises of 45 patients of age between (18-50)years old .They were divided into three groups, fifteen for each group , treatment involved mechanical therapy by scaling and polishing at dental clinic and drug treatment in which the first group applied to the mechanical treatment alone, , second group received chlorhexidine gel topically and third group received nanocinnamon gel topically , the treated groups used the gel twice daily at least ten minute for three weeks. Unstimulated saliva was collected for each individuals and at least two hours after any food intake to disregard the food stimulatory effect on salivary secretions. ELISA kits (Enzyme Linked Immunosorbent Assay) used to measure IL-6 and TNF-α in saliva . Data were analyzed using kruscal-wallias H test and Friedmans̓ test analysis range test. Results: the results of present study showed that there were no significant differences in salivary IL-6 among groups after treatment however , there were significantly decreasing in salivary TNF-α of nanocinnamon group after 21 days of interval therapy in comparison to control group. Conclusion :The use of nanocinnamon gel have anti-inflammatory effect against gingivitis and the changes in the salivary concentrations of IL-6 and TNF-α can help in the diagnosis of periodontal disease

al-rafidain dental journal/maǧallaẗ al-rāfidayn li-ṭibb al-asnān

Evaluate the Anti-inflammatory Effects of Nanocinnamon Gel on Salivary Cytokines: Tumor Necrosis factor-alpha (TNF-α) and Interleukine-6 (IL-6) in Chronic Gingivitis