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Bacterial persister cells are a subpopulation of isogenic bacteria with characteristics of reduced metabolic activity and multidrug antibiotic resistance. Our lab had previously proved that  Vibrio splendidus  could form persister cells both naturally and after stimulation. However, the conditions for the waking up of  V. splendidus  persister cells remain marginal. In this study, the carbon sources that could wake up  V. splendidus  persister cells were selected from 20 amino acids and eight saccharides. The result showed that L-glutamic acid, L-aspartic acid, L-arginine, L-phenylalanine, L-leucine, maltose, D-galactose, sorbitol, mannose, N-acetyl-D-glucosamine, D-glucose, and D-fructose could wake up the  V. splendidus  persister cells. The chemotaxis activity of both exponential cells and regrown persister cells on plate containing each of the selected carbon source are also high. The existence of the selected carbon source can affect the antibiotic susceptibility of  V. splendidus . When L-glutamic acid, L-aspartic acid, L-phenylalanine, and D-glucose were separately added into the cultured  V. splendidus  simultaneously with tetracycline,  V. splendidus  could be completely eliminated, while the addition of L-alanine and D-galactose could not. Our study suggested that  V. splendidus  persister cells could revive in the presence of specific carbon sources, and the addition of these exogenous nutrients could increase the tetracycline susceptibility of  V. splendidus .

Selection of the Amino Acid and Saccharide That Increase the Tetracycline Susceptibility of Vibrio splendidus