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AprV2  and  aprB2  are variants of the apr gene of  Dichelobacter nodosus , the cause of footrot in sheep. They are putative markers for severe and mild disease expression. The aim of our study was to investigate the distribution of  aprV2  and  aprB2  in flocks with and without footrot. Our hypotheses were that both strains are present in endemically affected flocks, with  aprB2  and  aprV2  associated with mild and virulent phenotypes respectively but that  D. nodosus  is not present in flocks without footrot. Alternatively,  aprB2  persists in flocks without footrot. Despite extensive searching over 3 years only three flocks of sheep without footrot were identified.  D. nodosus  was not detected in these three flocks. In one further flock, only mild interdigital dermatitis was observed, and only  aprB2  was detected. Twenty-four flocks with endemic footrot of all severities were sampled on three occasions and all were positive for  D. nodosus  and the  aprV2  variant;  aprB2  was detected in only 11 of these flocks.  AprB2  was detected as a co-infection with  aprV2  in the 22% of samples positive for  aprB2  and was more likely in mild footrot phenotypes than severe.  Dichelobacter nodosus  serogroups were not associated with footrot phenotype. We conclude that  D. nodosus , even  aprB2  strains, do not persist in flocks in the absence of footrot. Our results support the hypothesis that  aprB2  is associated with mild footrot phenotypes. Finally, we conclude that given the small number of flocks without footrot that were identified, footrot is highly endemic in English sheep flocks.

Impact of Strain Variation of Dichelobacter nodosus on Disease Severity and Presence in Sheep Flocks in England