English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Blood samples from 260 unrelated cattle (132 animals affected by papillomavirus-associated bladder tumors and 128 healthy) were genotyped using the classic polymerase chain reaction/restriction fragment length polymorphism method to screen MHC class II bovine leukocyte antigen-DRB3. 2 polymorphism. The DRB3 * 22 allele was significantly ( p  ≤ 0.01) detected in healthy cattle, thus appearing to have a negative association (protective effect) with virus infection of the urinary bladder known to represent a bladder tumor risk for cattle living free at pasture. Considering the two sequence alleles identified in animals carrying DRB3 * 22, DRB3 * 011:01 allele from samples of animals harboring the unexpressed bovine papillomaviruses (BPV)-2  E5  gene was characterized by amino acid residues believed to have a protective effect against BPV infection such as arginine at position 71 (R 71 ) in pocket 4, histidine at position 11 (H 11 ) in pocket 6, and both glutamine at position 9 (Q 9 ) and serine at position 57 (S 57 ) in pocket 9 of the antigen-binding groove. The DRB3 * 011:02v allele from affected animals was characterized by amino acids believed to be susceptibility residues such as lysine (K 71 ), tyrosine (Y 11 ), glutamic acid (E 9 ), and aspartic acid (D 57 ) in these pockets. These results suggest that animals harboring the DRB3 * 011:01 allele may have a lower risk of BPV infection and, consequently, a reduced risk of bladder tumors.

Association Between BoLA-DRB3.2 Polymorphism and Bovine Papillomavirus Infection for Bladder Tumor Risk in Podolica Cattle