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The urokinase-type plasminogen activator(PLAU) and its receptor PLAUR participate in a series of cell physiological activities on the extracellular surface. Abnormal expression of  PLAU  and  PLAUR  is associated with tumorigenesis. This study aims to evaluate the prognostic value of  PLAU/PLAUR  transcription expression in glioma and to explore how they affect the generation and progression of glioma. In this study, online databases are applied, such as Oncomine, GEPIA, CGGA, cBioPortal, and LinkedOmics. Overexpression of PLAU/PLAUR was found to be significantly associated with clinical variables including age, tumor type, WHO grade, histology, IDH-1 mutation, and 1p19q status.  PLAU  and  PLAUR  had a high correlation in transcriptional expression levels. High expression of  PLAU  and  PLAUR  predicted a poor prognosis in primary glioma and recurrent glioma patients, especially in lower grade gliomas. Cox regression analysis indicated that high expression of  PLAU  and  PLAUR  were independent prognostic factors for shorter overall survival in glioma patients. In gene co-expression network analysis  PLAU  and  PLAUR  and their co-expression genes were found to be involved in inflammatory activities and tumor-related signaling pathways. In conclusion, PLAU and PLAUR could be promising prognostic biomarkers and potential therapeutic targets of glioma patients.

Prognostic Significance and Gene Co-Expression Network of PLAU and PLAUR in Gliomas