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Alternative splicing is the process by which various combinations of exons are included in a mature mRNA, thus allowing a single gene to encode multiple protein isoforms with potentially different or even antagonistic properties. Proper mRNA splicing is absolutely crucial for nervous system development and its misregulation has been demonstrated in schizophrenia (Morikawa and Manabe, 2010). Schizophrenia is a severe and debilitating neuropsychiatric syndrome which has a complex etiology and is believed to arise from the interplay between genetic and environmental factors. Altered expression of genes involved in early migration of neurons and glia, cell proliferation, axonal outgrowth and synaptogenesis in schizophrenic patients support a neurodevelopmental model.

Development-related alternative splicing of PAC1 receptor: a key player in schizophrenia?