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action of DA at both or either population of receptors using the specific D1 and D2 antagonists, SCH-23390 and raclopride, respectively. Electrode microarrays chronically implanted in the dorsal striata of freely moving mice monitored changes in single unit and local field potential (LFP) activity following administration of the antagonists. The authors discriminated between the primary output neurons of the dorsal striatum, the medium spiny neurons (MSNs), and the fast-spiking interneurons and large aspiny neurons based upon the half-width, firing frequency, and ampli tude of the recorded waveforms. Single unit firing rate, relative power of differ ent frequency oscillations in the LFP, and entrainment of firing to the LFP (meas ured as spike-triggered average) were con

frontiers in neuroscience

Many Roads to Motor Deficits: Loss of Dopamine Signaling in Direct or Indirect Basal Ganglia Pathway Leads to Akinesia through Distinct Physiological Mechanisms