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Purpose:  This retrospective observational study aimed to investigate the self-reported prevalence of seizure clusters (SCs) in patients with epilepsy (PWE) and its relationship with clinical characteristics.   Methods:  We retrospectively analyzed data from consecutive PWE from our hospital in northeastern China. Data were collected from the databank of a tertiary epilepsy center. Logistic regression models were employed to investigate the relationships between the individual patient demographic/clinical variables and the occurrence of SC.   Results:  In total, 606 consecutive PWE were included in the final analysis, and 268 (44.2%) patients experienced at least one seizure cluster. In multivariate logistic regression models, age (OR: 1.014; 95% CI: 1.002–1.027;  p  = 0.02), seizure frequency (OR: 2.08; 95% CI: 1.555–2.783;  p  &amp;lt; 0.001), multiple seizure types (OR: 5.111; 95% CI: 1.737–15.043;  p  = 0.003), number of current anti-seizure medications (ASM) (OR: 1.533; 95% CI: 1.15–2.042;  p  = 0.004), drug-resistant epilepsy (OR: 1.987; 95% CI: 1.159–3.407;  p  = 0.013), and a history of status epilepticus (OR: 1.903; 95% CI: 1.24–2.922;  p  = 0.003) were independent variables associated with a history of SC in PWE.   Conclusion:  Seizure clusters (SCs) are common occurrences at our study center. The occurrence of SC in individuals with epilepsy, to some extent, is determined by the epilepsy severity.

frontiers in neurology

The Occurrence of Seizure Clusters in Patients With Epilepsy Is Partly Determined by Epilepsy Severity: A Single-Center Retrospective Observational Study