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C1ORF112  is an evolutionarily conserved gene across vertebrates. Over the last decade, studies have suggested that  C1ORF112  may play a role in tumorigenesis. Using The Cancer Genome Atlas datasets, we explored the role of  C1ORF112  across various tumor types in this study. In most tumor types,  C1ORF112  expression was increased in tumor tissues compared to corresponding non-tumor tissues. In patients with certain tumor types, higher  C1ORF112  expression was correlated with shorter overall survival, disease-free survival, and progression-free survival. Further analyses of  C1ORF112  genetic alteration data showed that  C1ORF112  amplification and mutations may have an impact on liver hepatocellular carcinoma and uterine corpus endometrial carcinoma prognosis. In cancers including lower grade glioma and adrenocortical carcinoma,  C1ORF112  expression was linked to cancer-associated fibroblast infiltration. Gene Ontology analysis showed that  C1ORF112  was co-expressed with genes involved in biological processes such as cell cycle and mitotic regulation. The protein interaction network demonstrated that  C1ORF112  physically interacted with  RAD51 ,  DMC1 , and  FIGNL1 , which have well characterized functions in DNA repair and cell cycle regulation. This pan-cancer study revealed the prognostic value and oncogenic role of  C1ORF112  across multiple tumor types.

Pan-Cancer Analysis Identified C1ORF112 as a Potential Biomarker for Multiple Tumor Types