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Background:  Previous studies demonstrated that  miRNA-1827  could repress various cancers on proliferation, angiogenesis, and metastasis. However, little attention has been paid to its role in ovarian cancer as a novel biomarker or intervention target, especially its clinical significance and underlying regulatory network.    Methods:  A meta-analysis of six microarrays was adopted here to determine the expression trend of  miRNA-1827 , and was further validated by gene expression profile data and cellular experiments. We explored the functional annotations through enrichment analysis for the differentially expressed genes targeted by  miRNA-1827 . Subsequently, we identified two hub genes,  SPTBN2  and  BCL2L1 , based on interaction analysis using two online archive tools, miRWALK (it consolidates the resources of 12 miRNA-focused servers) and Gene Expression Profiling Interactive Analysis (GEPIA). Finally, we validated their characteristics and clinical significance in ovarian cancer.    Results:  The comprehensive meta-analysis revealed that  miRNA-1827  was markedly downregulated in clinical and cellular specimens. Transfection of the  miRNA-1827  mimic could significantly inhibit cellular proliferation. Concerning its target genes, they were involved in diverse biological processes related to tumorigenesis, such as cell proliferation, migration, and the apoptosis signaling pathway. Moreover, interaction analysis proved that two hub genes,  SPTBN2  and  BCL2L1 , were highly associated with poor prognosis in ovarian cancer.    Conclusion:  These integrated bioinformatic analyses indicated that  miRNA-1827  was dramatically downregulated in ovarian cancer as a tumor suppressor. The upregulation of its downstream modulators,  SPTBN2  and  BCL2L1 , was associated with an unfavorable prognosis. Thus, the present study has identified  miRNA-1827  as a potential intervention target for ovarian cancer based on our bioinformatic analysis processes.

A Comprehensive Analysis of the Downregulation of miRNA-1827 and Its Prognostic Significance by Targeting SPTBN2 and BCL2L1 in Ovarian Cancer