English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

The emergence of resistant  Aspergillus  spp. is increasing worldwide. Long-term susceptibility surveillance for clinically isolated  Aspergillus  spp. strains is warranted for understanding the dynamic change in susceptibility and monitoring the emergence of resistance. Additionally, neither clinical breakpoints (CBPs) nor epidemiological cutoff values (ECVs) for  Aspergillus  spp. in China have been established. In this study, we performed a 20-year antifungal susceptibility surveillance for 706 isolates of  Aspergillus  spp. in a clinical laboratory at Peking University First Hospital from 1999 to 2019; and  in vitro  antifungal susceptibility to triazoles, caspofungin, and amphotericin B was determined by the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method. It was observed that  Aspergillus fumigatus  was the most common species, followed by  Aspergillus flavus  and  Aspergillus terreus . Forty isolates (5.7%), including  A. fumigatus ,  A. flavus ,  A. terreus ,  Aspergillus niger , and  Aspergillus nidulans , were classified as non-wild type (non-WT). Importantly, multidrug resistance was observed among  A. flavus ,  A. terreus , and  A. niger  isolates.  Cyp51A  mutations were characterized for 19 non-WT  A. fumigatus  isolates, and TR 34 /L98H/S297T/F495I was the most prevalent mutation during the 20-year surveillance period. The overall resistance trend of  A. fumigatus  increased over 20 years in China. Furthermore, based on ECV establishment principles, proposed ECVs for  A. fumigatus  and  A. flavus  were established using gathered minimum inhibitory concentration (MIC)/minimum effective concentration (MEC) data. Consequently, all the proposed ECVs were identical to the CLSI ECVs, with the exception of itraconazole against  A. flavus , resulting in a decrease in the non-WT rate from 6.0 to 0.6%.

frontiers in microbiology

A 20-Year Antifungal Susceptibility Surveillance (From 1999 to 2019) for Aspergillus spp. and Proposed Epidemiological Cutoff Values for Aspergillus fumigatus and Aspergillus flavus: A Study in a Tertiary Hospital in China