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Aim:  To evaluate the effect of Selenium-enriched  Lactobacillus acidophilus  (Se-enriched  L. acidophilus ) on dextran sulfate sodium (DSS)-induced colitis in mice.   Methods:  Mice were randomly divided into four groups: a control group, a control + Se-enriched  L. acidophilus  group, a chronic colitis group, and a chronic colitis + Se-enriched  L. acidophilus  group ( n  = 10 each group). The mice were sacrificed on the 26th day. The disease activity index, survival rates, and histological injury score were determined. Cytokines produced by lamina propria lymphocytes (LPLs), the selenium (Se) concentrations in serum and colon tissue and the mouse intestinal microbiota were evaluated.   Results:  Se-enriched  L. acidophilus  can improve histological injury and the disease activity index in mice with chronic colitis and reduce IL-1β, IL-6, IL-12p70, TNF-α, IL-23, IFN-γ, IL-17A, and IL-21 ( P  < 0.05) and increase IL-10 ( P  < 0.05) expression levels. Moreover, Se-enriched  L. acidophilus  can increase the β diversity of intestinal microbiota in mice with chronic colitis, significantly reduce the relative abundance of  Lactobacillus  and  Romboutsia  ( P  < 0.05), and significantly increase the relative abundance of  Parasutterella  ( P  < 0.05).   Conclusions:  Se-enriched  L. acidophilus  can improve DSS-induced chronic colitis by regulating inflammatory cytokines and intestinal microbiota.

frontiers in medicine

Selenium-Enriched Lactobacillus acidophilus Ameliorates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice by Regulating Inflammatory Cytokines and Intestinal Microbiota