English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background:  Haemophilus parasuis  ( Hps ; now  Glaesserella parasuis ) is an infectious agent that causes severe arthritis in swines and shares sequence similarity with residues 261–273 of collagen type 2 (Coll 261−273 ), a possible autoantigen in rheumatoid arthritis (RA).   Objectives/methods:  We tested the presence of  Hps  sequencing 16S ribosomal RNA in crevicular fluid, synovial fluids, and tissues in patients with arthritis (RA and other peripheral arthritides) and in healthy controls. Moreover, we examined the cross-recognition of  Hps  by Coll 261−273 -specific T cells in HLA-DRB1 * 04 pos  RA patients, by T-cell receptor (TCR) beta chain spectratyping and T-cell phenotyping.   Results:  Hps  DNA was present in 57.4% of the tooth crevicular fluids of RA patients and in 31.6% of controls. Anti- Hps  IgM and IgG titers were detectable and correlated with disease duration and the age of the patients. Peripheral blood mononuclear cells (PBMCs) were stimulated with  Hps  virulence-associated trimeric autotransporter peptide (VtaA10 755−766 ), homologous to human Coll 261−273  or co-cultured with live  Hps . In both conditions, the expanded TCR repertoire overlapped with Coll 261−273  and led to the production of IL-17.   Discussion:  We show that the DNA of an infectious agent ( Hps ), not previously described as pathogen in humans, is present in most patients with RA and that an  Hps  peptide is able to activate T cells specific for Coll 261−273 , likely inducing or maintaining a molecular mimicry mechanism.   Conclusion:  The cross-reactivity between VtaA10 755−766  of a non-human infectious agent and human Coll 261−273  suggests an involvement in the pathogenesis of RA. This mechanism appears emphasized in predisposed individuals, such as patients with shared epitope.

Haemophilus parasuis (Glaesserella parasuis) as a Potential Driver of Molecular Mimicry and Inflammation in Rheumatoid Arthritis