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Circulatory inflammatory proteins play a significant role in anti- Candida  host immune defence. However, little is known about the genetic variation that contributes to the variability of inflammatory responses in response to  C. albicans . To systematically characterize inflammatory responses in  Candida  infection, we profiled 91 circulatory inflammatory proteins in peripheral blood mononuclear cells (PBMCs) stimulated with  C. albicans  yeast isolated from 378 individuals of European origin from the 500 Functional Genomics (500FG) cohort of the Human Functional Genomics Project (HFGP) and Lifelines Deep cohort. To identify the genetic factors that determine variation in inflammatory protein responses, we correlated genome-wide single nucleotide polymorphism (SNP) genotypes with protein abundance (protein quantitative trait loci, pQTLs) produced by the  Candida -stimulated PBMCs. Furthermore, we investigated whether differences in survival of candidaemia patients can be explained by modulating levels of inflammatory proteins. We identified five genome-wide significant pQTLs that modulate IL-8, MCP-2, MMP-1, and CCL3 in response to  C. albicans . In addition, our genetic analysis suggested that  GADD45G  from rs10114707 locus that reached genome-wide significance could be a potential core gene that regulates a cytokine network upon  Candida  infection. Last but not least, we observed that a trans-pQTL marked from SNP rs7651677 at chromosome 3 that influences urokinase plasminogen activator (uPA) is strongly associated with patient survival ( P   survival  = 3.52 x 10 -5 , OR 3). Overall, our genetic analysis showed that genetic variation determines the abundance of circulatory proteins in response to  Candida  infection.

Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability